KETONE PHARMA

N-O-Dimethylhydroxylamine (DMHA) is an organic compound used in chemical synthesis, often as a reducing agent or intermediate.

What is N-O-Dimethylhydroxylamine Hydrochloride?

 

N-O-Dimethylhydroxylamine Hydrochloride (DMHA·HCl) is a versatile organic compound widely used in organic synthesis, pharmaceuticals, and agrochemical research. It’s the hydrochloride salt form of N,O-dimethylhydroxylamine, which improves its stability and handling in lab environments.

Chemical Structure & Formula

• Chemical Formula: C2H8ClNO

• Molecular Weight: 97.55 g/mol

• Structure: It consists of a dimethylated nitrogen bound to a hydroxylamine group, stabilized by a hydrochloride salt.

Why is it Important?

DMHA·HCl is a valuable reagent, especially in amide bond formation. It’s frequently used in the preparation of Weinreb amides, which are key intermediates in the selective synthesis of ketones from acyl chlorides or esters. These reactions are common in pharmaceutical development and natural product synthesis.

Applications:

• Pharmaceutical intermediates

• Agrochemical development

• Organic synthesis research

• Weinreb amide preparation

Handling and Safety:

While DMHA·HCl is relatively stable, it should be handled in a well-ventilated lab using proper personal protective equipment (PPE). As with many amine-based reagents, it may be harmful if inhaled or swallowed, and can irritate skin and eyes.

Storage Tips:

• Store in a cool, dry place

• Keep container tightly closed

• Protect from moisture

In Summary

N-O-Dimethylhydroxylamine HCl is a powerful and practical reagent for modern organic chemists. Whether you're synthesizing a complex pharmaceutical molecule or a custom intermediate, this compound often plays a crucial behind-the-scenes role.